1. tuaj yeem txhim kho solubility, solubility tus nqi, stability thiab bioavailability;
2. Qhov chaw tso tshuaj thiab/lossis lub sij hawm nkhaus tuaj yeem hloov kho;
3. Nws tuaj yeem txo lossis tiv thaiv kev mob plab hnyuv thiab tsis hnov tsw tsw los yog saj, tiv thaiv kev siv tshuaj yeeb lossis tshuaj ntxiv, thiab txawm hloov cov roj thiab kua tshuaj rau hauv microcrystalline lossis amorphous hmoov.
Ib qho kev sib txawv tsis ntev los no tau siv ntawm 2-hydroxypropyl - -cyclodextrinraws li ib tug nanocarrier, ib lub tswv yim tsim los tsim multifunctional tshuaj xa tshuab uas muaj peev xwm encapsulate tshuaj nrog zoo physicochemical zog rau qhov ncauj. Yog li ntawd, lub hom phiaj ntawm txoj kev tshawb no yog coj kom zoo dua ntawm daim ntawv thov ntawm 2- hydroxypropyl- -cyclodextrin thiab nws cov hydrophilic derivatives nyob rau hauv ua kom cov solubility ntawm cov dej-soluble tshuaj uas tsis tshua muaj soluble kom lawv dissolution tus nqi thiab tam sim ntawd tso tawm, nrog rau lawv lub peev xwm tswj tau (ntev lossis ncua sijhawm) tso tawm cov tshuaj los ntawm cov ntaub ntawv ntau npaum li cas, raws li cov complexes nrog hydrophilic (xws li osmotic twj) thiab / lossis hydrophobic CDs.
2- hydroxypropyl- -cyclodextrin yog hydroxylated derivative ntawm betacyclodextrin (-CD). 2- hydroxypropyl- -cyclodextrin yog non-toxic thiab tsis muaj kev phiv. Vim nws cov qauv tshwj xeeb, nws tuaj yeem txhim kho cov solubility ntawm cov tshuaj insoluble thiab ua rau cov tshuaj insoluble lossis insoluble yaj hauv dej. Yog li ntawd, nws tuaj yeem txhim kho bioavailability ntawm cov tshuaj, tuaj yeem txhim kho cov tshuaj zoo thiab ntau npaum li cas, thiab siv dav hauv kev txhim kho thiab tsim cov tshuaj tshiab.
Shandong Binzhou Zhiyuan cov khoom siv roj ntsha thiab cov chaw soj ntsuam tau ua tiav, nrog rau kev cob qhia siab GMP. Tau txais ISO9001 daim ntawv pov thawj kev ua haujlwm zoo, yog li kev ua tiav tag nrho cov txheej txheem ntawm cyclodextrin ntau lawm. Cov khoom zoo los ntawm cov khoom siv raw khoom, tshuaj xyuas rau tag nrho cov txheej txheem ntau lawm, warehouse nkag thiab tawm, nruj kev siv cov txheej txheem txheej txheem. Ua kom muaj kev tswj xyuas zoo thiab kev saib xyuas rau txhua qhov txuas, thiab tsis tu ncua kev sib tham txog cov teeb meem kev soj ntsuam zoo los daws cov teeb meem zoo uas tau ntsib hauv cov txheej txheem tsim khoom. Qhov ncauj qib 2- hydroxypropyl- -cyclodextrin cov qauv khoom raws li USP/EP/CP, CDE tus naj npawb: F20209990366, DMF NO. ib: 030168.
