Ntuj Cyclodextrin

Muaj peb hom natural cyclodextrins, , thiab cyclodextrins, uas tau muab rho tawm thiab ua tiav los ntawm cov hmoov txhuv nplej siab los yog pob kws hmoov nplej, thiab tau siv dav hauv kev kho tshuaj thiab kev tsim khoom noj.

Α-cyclodextrin yog tsim rau qib siab tsw, tshuaj tsw qab, tshuaj pleev ib ce thiab kev lag luam tshuaj; -cyclodextrin tuaj yeem siv rau hauv cov khoom noj, tshuaj thiab tshuaj pleev ib ce; -cyclodextrins muaj cov kab noj hniav loj dua -cyclodextrins, tuaj yeem suav nrog ntau yam ntawm cov qhua molecules, thiab muaj cov dej solubility zoo dua.

Zhiyuan: Koj Trustworthy Natural Cyclodextrin Chaw Tsim Tshuaj!

Shandong Binzhou Zhiyuan Biotechnology Co., Ltd yog tus thawj coj ncaj qha ntawm cyclodextrin derivatives, cyclodextrin inclusion compounds thiab cyclodextrin reagents. Tsim los ntawm 2010, peb lub tuam txhab npog thaj tsam ntawm 30, 000 square metres, nrog thaj tsam ntawm 10, 000 square meters. Peb muaj peb tus kheej GMP tus qauv kws tshuaj excipient huv kev cob qhia ntau lawm, lub tsev muag tshuaj loj, thiab chaw soj ntsuam zoo. Tsis tas li ntawd, peb tau tsim cov txheej txheem los txheeb xyuas cov xwm txheej ntawm cov khoom ntawm txhua theem thiab saib xyuas lawv cov khoom siv raw, cov txheej txheem, kev soj ntsuam zoo, thiab lwm yam kom ntseeg tau tias cov khoom no tuaj yeem siv nyab xeeb hauv tshuaj, khoom noj, tshuaj pleev ib ce, tshuaj tsw qab, tshuaj tua kab thiab lwm yam. teb.

Cov khoom lag luam nplua nuj

Peb muaj ntau tshaj 70 hom cyclodextrin nyob rau hauv 5 series loj (natural cyclodextrins, cyclodextrin derivatives, cyclodextrin reagents, cyclodextrin complexes, thiab cyclodextrin polymers), thiab ua kev tshawb fawb thiab kev loj hlob rau txawv daim ntaub ntawv ntawm cov khoom tshiab.

Khoom zoo

Peb GMP Rhiav tau txais daim ntawv tso cai tsim tshuaj hauv xyoo 2013 thiab dhau ISO daim ntawv pov thawj. Tam sim no nws tau nruab nrog ion chromatography (Ic), capillary electrophoresis (Ce), high-performance kua chromatography, thiab Fourier transform infrared spectrometer (Ftir) thiab lwm yam khoom siv kuaj.

Quality Assurance

Tag nrho peb cov khoom, suav nrog hydroxypropyl dex, -butanesulfonate sodium thiab hydroxypropyl -cyclodextrin, tau sau npe los ntawm DMF, pom zoo los ntawm US FDA, thiab tau dhau ntau daim ntawv pov thawj xws li CP, USP, thiab EP.

Customizable Services

Peb muaj kev ua tiav R & D, chaw soj ntsuam zoo thiab pab pawg tsim khoom. Peb tuaj yeem hloov kho cov khoom lag luam cyclodextrin raws li koj xav tau, suav nrog lawv qhov ntau, cov khoom xyaw, ntim, thiab txhawb OEM thiab ODM xaj.

Dab tsi yog Natural Cyclodextrin?

Cyclodextrins yog ib tsev neeg ntawm cyclic oligosaccharides, muaj ib lub nplhaib macrocyclic ntawm qabzib subunits koom los ntawm -1,4 glycosidic bonds. Cyclodextrins yog tsim los ntawm cov hmoov txhuv nplej siab los ntawm enzymatic hloov dua siab tshiab, los ntawm tej yam ntuj tso xws li pob kws, qos yaj ywm, cassava, thiab pob kws starches. Lawv yog siv nyob rau hauv cov zaub mov, tshuaj, xa tshuaj, thiab tshuaj industries, raws li zoo raws li kev ua liaj ua teb thiab ib puag ncig engineering.
They are composed of 5 or more α-D-glucopyranoside units linked 1->4, raws li nyob rau hauv amylose (ib feem ntawm starch). Lawv muab faib ua peb hom.

(alpha)-cyclodextrin: 6 qabzib subunits
(beta)-cyclodextrin: 7 qabzib subunits
(gamma)-cyclodextrin: 8 glucose subunits

Cov yam ntxwv zoo tshaj plaws ntawm cyclodextrin muaj 32 1, 4-anhydroglucopyranoside units. Cov khoom sib xyaw tsis zoo, muaj tsawg kawg yog 150-cov tswvcuab cyclic oligosaccharides kuj paub.

Nta ntawm Ntuj Cyclodextrin

Muaj ntau yam
Peb lub ntuj cyclodextrins yog qhov zoo tshaj plaws kom haum rau biomolecules loj dua thiab lwm tus qhua, thiab lwm yam khoom tuaj yeem nqus tau rau hauv lawv cov kab noj hniav molecular, tsim cov tshuaj molecular capsules uas cais lawv los ntawm ib puag ncig cuam tshuam.

Dissolve ceev
Cov cyclodextrins yog cov khoom noj khoom haus uas muaj kuab heev uas muaj cov dej solubility hauv dej, roj lossis lwm yam kua los ua zaub mov, tshuaj pleev ib ce, textiles, tshuaj thiab lwm yam khoom.

Qhov xwm txheej ruaj khov
Lawv nce solubility thiab stability ntawm cov tshuaj vim hais tias lawv muaj hydrophobic zog uas tso cai rau lawv nkag mus rau tib neeg cov ntaub so ntswg thiab tso bioactive compounds nyob rau hauv tej yam kev mob.

Yooj yim rau Khw
Cov cyclodextrins tej yam ntuj tso tau yooj yim khaws cia nyob rau hauv ib qho chaw txias, qhuav thiab tsis tas yuav tsum tau tub yees los yog kub tswj, tab sis lawv yuav tsum tau khaws cia kom deb ntawm tshav ntuj ncaj qha thiab tshav kub qhov chaw.

Daim ntawv thov ntawm Natural Cyclodextrin

Kev lag luam zaub mov
CDs feem ntau yog siv rau hauv cov khoom noj rau lub encapsulation ntawm cov ntsiab lus ntawm kev txaus siab thiab kev txhim kho cov dej tuav, vim lawv yog hygroscopic compounds. Lawv siv tau tuaj yeem txhim kho ntau yam zoo, xws li ntau homogeneous compositions uas yooj yim dua los ua tus qauv. Ntau daim ntawv thov ntawm CDs tau piav qhia, piv txwv li, txhim kho cov kab mob organoleptic zoo (tag nrho lossis ib feem tshem tawm ntawm cov khoom tsis zoo / tsw), ua kom lub neej txee rau khoom noj khoom haus, kev sib xyaw ua ke, thiab kev xaiv emulsions, thiab lwm yam.

Kev siv tshuaj
CDs yog siv rau ntau lub hom phiaj hauv kev siv tshuaj. Hauv kev tsim tshuaj, CDs tau piav qhia los ua kom bioavailability, solubility, stability, txo hemolysis thiab phiv los, tiv thaiv admixture incompatibilities thiab ua raws li excipients, ntawm lwm yam kev siv. Txhim kho cov solubility ntawm cov tshuaj yog qhov nthuav, vim hais tias cov compound yuav muaj kev kho mob ntau dua, thiab cov tshuaj qis dua yuav tsim nyog. Ntau cov tshuaj tiv thaiv kab mob CDs tau raug tshuaj xyuas. CDs kuj tau siv los xa cov oligosaccharides, cov proteins, thiab oligonucleotides vim lawv lub peev xwm los cuam tshuam nrog cellular membranes, txhim kho cellular uptake. Lwm daim ntawv thov yog xa cov tshuaj tua kab mob, xws li plasmids, kab mob vectors, thiab antisense constructs.

Tshuaj pleev ib ce thiab kho tus kheej
CDs kuj siv yog tshuaj pleev ib ce. Nws daim ntawv thov muaj ntau yam zoo, xws li stabilizing tebchaw, tau txais cov ntxhiab thiab tsw ntawm ntau dua kev lees paub, kev txhim kho qhov kev txiav txim ntawm cov compound los ntawm kev hloov cov kua ua kua rau hauv daim ntawv, txo vapor siab, hloov cov solubility hauv dej, thiab txhim kho thermal stability. ntawm cov roj, thiab lwm yam. Lawv yog siv nyob rau hauv kev tawm tsam ntawm volatility ntawm perfumes, cua fresheners, thiab detergents txij li thaum lawv tso cai rau ib tug tswj kev tso tawm ntawm fragrances los ntawm tus tswv tsev - qhua complex, ua ntau tsis ntseeg fragrances. Lawv kuj tau siv rau hauv kev tsim cov tshuaj txhuam hniav, tshuaj pleev xim rau ntawm daim tawv nqaij, ntaub softeners (kua thiab khoom), ntawv phuam, ntaub so ntswg, thiab underarm shields. Yog li, CDs sawv cev rau kev txhawb nqa tsim nyog, txij li lawv tuaj yeem txhim kho kev ua tau zoo ntawm cov khoom lag luam thiab daws cov teeb meem uas yuav tshwm sim thaum nws tsim.

Ntim thiab Textile Kev Lag Luam
Nyob rau hauv xyoo tas los no, kev lag luam textile tau qhia nws txoj kev tshawb fawb txog kev ua haujlwm thiab kev ruaj khov fabrics. Hauv daim teb no, -CDs tuaj yeem ua lub luag haujlwm tseem ceeb vim nws tuaj yeem tsim cov complexes nrog ntau hom kev sib txuas, uas ua rau muaj ntau yam tshiab ntawm cov khoom siv textile thiab kev siv nrog cov khoom zoo, xws li tshuaj tua kab mob lossis photoprotective. Kev sib koom ua ke ntawm CDs rau cov ntaub ntawv kuj tseem tuaj yeem ua rau xa cov ntxhiab tsw thiab ntes cov malodors (hws, pa luam yeeb) lossis ua kom muaj peev xwm ntawm cov ntaub kom khaws cov xim nrog cov txiaj ntsig zoo ntawm kev txo qis hauv cov dej khib nyiab. Tsis tas li ntawd, lawv tuaj yeem ua cov nplaim hluav taws. Hauv cov tshuaj, cov ntaub so ntswg kho mob uas muaj CDs yog siv los tso cov tshuaj sib txuas (ob qho tib si hauv lub cev lossis hauv lub cev) nrog cov khoom muaj txiaj ntsig, xws li tshuaj tua kab mob, tiv thaiv kev ua xua, tshuaj tua kab mob, tiv thaiv kab mob, thiab tiv thaiv kab.

Hom Ntuj Cyclodextrin

-Cyclodextrin (alpha-cyclodextrin)

Qee zaum abbreviated li -CD, yog hexasaccharide muab tau los ntawm qabzib. Nws muaj feem xyuam rau - (beta) thiab - (gamma) cyclodextrins, uas muaj xya thiab yim piam thaj units, raws li. Tag nrho cov cyclodextrins yog dawb, dej-soluble solids nrog tsawg toxicity. Cyclodextrins nyiam khi lwm cov molecules nyob rau hauv lawv quasi-cylindrical, lipophilic interiors. Qhov sib xyaw ua ke yog qhov kev txaus siab dav vim nws nthuav tawm cov tswv tsev-cov qhua, tsim cov sib xyaw ua ke. Qhov kev suav nrog (thiab tso tawm) tus cwj pwm no ua rau kev siv tshuaj.

Nyob rau hauv -cyclodextrin, rau lub qab qab zib subunits yog txuas mus rau kawg ntawm -1, 4 linkages. Qhov tshwm sim muaj cov duab ntawm lub tog raj kheej tapered, nrog rau 6 thawj cawv ntawm ib lub ntsej muag thiab kaum ob pawg cawv ntawm lwm qhov. Sab nrauv ntawm cyclodextrins yog me ntsis hydrophilic thaum lub hauv paus tseem ceeb yog hydrophobic. -Cyclodextrin yog muag rau ntau yam kev kho mob, kev kho mob, thiab kev siv zaub mov thiab dej haus. Rau kev xa tshuaj, qhov no cyclodextrin confers aqueous solubility rau hydrophobic tshuaj thiab stability rau labile tshuaj.

- Cyclodextrin

Qee zaum abbreviated li -CD, yog heptasaccharide muab tau los ntawm qabzib. Cov - (alpha), - (beta), thiab - (gamma) cyclodextrins sib haum mus rau rau, xya, thiab yim piam thaj units, feem. -Cyclodextrin yog lub ntuj siv tshaj plaws cyclodextrin hauv khw muag tshuaj. Yog vim li cas rau qhov no nyob rau hauv qhov yooj yim ntawm nws cov ntau lawm thiab cov nqi qis tom qab (ntau dua 10,000 tons tsim txhua xyoo nrog tus nqi nruab nrab ntawm kwv yees li 5 USD ib kg).

Nyob rau hauv -cyclodextrin, xya qab zib subunits yog txuas kawg mus rau kawg ntawm -1,4 linkages. Qhov tshwm sim muaj cov duab ntawm lub tog raj kheej tapered, nrog xya thawj cawv ntawm ib lub ntsej muag thiab kaum plaub pawg cawv thib ob ntawm lwm qhov. Sab nrauv ntawm cyclodextrins yog me ntsis hydrophilic thaum lub hauv paus tseem ceeb yog hydrophobic. -Cyclodextrin yog dav siv hauv tshuaj, tsev muag tshuaj, kev lag luam zaub mov, textiles. Nws cov molecules tuaj yeem ua kom haum rau ntau yam biomolecules thiab yog li no kuj siv los ua tus neeg sawv cev complexing.

- Cyclodextrin

Qee zaum abbreviated li -CD, yog octasaccharide muab tau los ntawm cov piam thaj. Hauv -cyclodextrin, yim cov piam thaj subunits txuas mus rau qhov kawg ntawm -1,4 linkages. Qhov tshwm sim muaj cov duab ntawm lub tog raj kheej tapered, nrog 8 thawj cawv ntawm ib lub ntsej muag thiab 16 pawg cawv thib ob ntawm lwm qhov. Sab nrauv ntawm cyclodextrins yog me ntsis hydrophilic thaum lub hauv paus tseem ceeb yog hydrophobic.

-Cyclodextrin muaj nyob hauv cov hmoov dawb (tsis muaj xim) lossis muaju. Qhov ceev ntawm nws cov hydrate crystal (CD·14H2O) yog 1.41 g / cm3. -Cyclodextrin zoo soluble hauv dej thiab dimethyl sulfoxide, tsis zoo soluble hauv methanol. -Cyclodextrins muaj qhov loj tshaj plaws kab noj hniav ntawm tej yam ntuj tso cyclodextrin, yog li, nws yog zoo-tsim kom haum raws li loj biomolecules thiab lwm yam qhua. Vim li no, -cyclodextrin feem ntau yog siv los ua tus neeg sawv cev complexing. -Cyclodextrin yog dav siv hauv tshuaj, chaw muag tshuaj, kev lag luam zaub mov, tshuaj pleev ib ce, textiles.

Inclusion Complexes Npaj cov txheej txheem ntawm Ntuj Cyclodextrin

Cov txheej txheem npaj siv kom tau txais kev suav nrog cov complexes plays lub luag haujlwm tseem ceeb vim nws cuam tshuam rau kev ua tau zoo thiab cov yam ntxwv ntawm cov khoom. Muaj ntau txoj hauv kev rau kev npaj cyclodextrin-tus qhua complexes, ntawm cov uas tseem ceeb yog: txoj kev sib koom ua ke nag lossis daus, txoj kev kneading, supercritical carbon dioxide txoj kev, txoj kev sib tsoo, txoj kev microwave irradiation thiab tshuaj tsuag kom qhuav.

Tag nrho nag lossis daus

Co- nag lossis daus yog tsim rau cov dej-insoluble tshuaj, thiab nyob rau hauv cov txheej txheem no kom tau inclusion complexes, ib tug ethanolic tov uas muaj cov qhua yog ntxiv rau CD yaj nyob rau hauv dej nrog stirring. Cov qhua tuaj yeem yaj hauv cov kuab tshuaj sib txawv (xws li ether lossis benzene, thiab lwm yam), thiab tom qab ntawd cov tshuaj tau txias, crystallization thiab nag lossis daus tshwm sim. Tom qab ntawd, ntxuav cov lim tshem tawm cov qhua dawb ntawm CD nto. Ib yam li ntawd, nag lossis daus ntawm complexes tuaj yeem ua tiav los ntawm kev siv cov tshuaj tua kab mob. Co-precipitation yog suav tias yog ib qho ntawm cov kev siv ntau tshaj plaws thiab sawv tawm rau nws txoj kev yooj yim thiab kev ua haujlwm.

Pinch Txoj Kev

Qhov no (tseem hu ua txoj kev muab tshuaj txhuam) yog ib txoj hauv kev yooj yim uas qhov hnyav hnyav ntawm cyclodextrin yog tov nrog ib qho me me ntawm cov dej huv (hauv mortar) kom tau txais cov muab tshuaj txhuam. Cov qhua yog muab tso rau hauv qhov muab tshuaj txhuam thiab sib tov zoo, thiab tom qab ntawd ntxuav cov khoom tau nrog me me ntawm cov kuab tshuaj. Cov txheej txheem tau tshaj tawm tias yog qhov yooj yim heev, ua haujlwm tau zoo thiab scalable.

Supercritical Carbon Dioxide Txoj Kev

Peb qhia txog qhov yuav tsum tau muaj ntawm cyclodextrin thiab qhua rau hauv autoclave, uas yog isothermal thiab pressurized nrog carbon dioxide ntawm lub siab thiab kub. Cov pa roj carbon dioxide ces evaporates vim qhov poob siab sai thiab cov clathrate sib cais. Supercritical kua yog siv dav hauv cov txheej txheem lag luam sib txawv thiab kev tshawb fawb. Vim lawv cov khoom xws li cov ntsiab lus tseem ceeb thiab tsis tshua muaj tshuaj lom, cov kua dej supercritical yog cov kuab tshuaj tshaj plaws rau carbon dioxide.

Txoj kev sib tsoo

Thaum sib tov ntawm cov qhua thiab cyclodextrins raug rau cov neeg kho tshuab zog sib tsoo, cov tebchaw tuaj yeem tau txais lub zog txaus thaum muaj kev sib tsoo ntawm cov xov xwm sib tsoo, uas ua rau muaj kev sib txuam ntawm quasi-adiabatic zog, tso cai rau kev tsim cov txheej txheem metastable. Cov txheej txheem kev sib tsoo no ua rau cov pob zeb tawg, ua rau txo qis hauv qhov loj me thiab nce hauv qhov chaw sib cuag rau kev sib cuam tshuam ntawm cov qhua thiab cyclodextrin. Txoj kev siv tshuab no yog ib qho yooj yim thiab feem ntau siv cov txheej txheem hauv kev lag luam kws tshuaj thiab tsis tas yuav muaj cov kuab tshuaj sib txawv los ua thiab tuaj yeem suav tias yog txoj kev huv thiab ib puag ncig tus phooj ywg.

Microwave Radiation

Qhov no yog ib txoj hauv kev npaj cov sib xyaw ua ke siv lub qhov cub microwave. Sib tov cov qhua thiab CD hauv ib qho me me ethanol / dej sib tov thiab muab tso rau hauv lub microwave kom thaum kawg tau hmoov. Txhawm rau tshem tawm cov khoom seem, ntxuav cov hmoov nrog ethanol. Piv nrog rau cov kev cai ib txwm muaj, qhov zoo tshaj plaws ntawm cov cuab yeej no yog tias tsis muaj qhov seem uas tshwm sim los ntawm kev siv cov kuab tshuaj organic ntau ntau.

Txau kom qhuav

Cov thev naus laus zis yog tus cwj pwm los ntawm peb kauj ruam: atomization ntawm cov kua pub, ziab ntawm cov tee dej zoo siv cov cua kub cua sov, thiab cov kauj ruam kawg uas cais cov khoom qhuav los ntawm cov kwj deg. Qhov zoo ntawm cov thev naus laus zis no yog qhov yooj yim rau kev thov ntawm qib kev lag luam. Txawm li cas los xij, raws li tau tshaj tawm, txoj kev no tsuas yog siv rau cov dej-dispersed los yog dej-soluble carrier matrix cov ntaub ntawv thiab muaj qhov zoo ntawm cov zis siab, ceev kom qhuav ceev, thiab tsim nyog rau cov khoom loj hauv kev lag luam khoom noj.

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Cov lus nug nquag nug txog Ntuj Cyclodextrin

Q: Dab tsi yog qhov ntuj tsim ntawm cyclodextrin?

A: Cyclodextrins (CDs) yog ib hom cyclic oligosaccharide muab tau los ntawm tej yam ntuj tso xws li qos yaj ywm, pob kws, pob kws, thiab cassava starches. Cov cyclodextrins yog cais raws li -CDs, -CDs, thiab -CDs.

Q: Yuav ua li cas yog cyclodextrin muab tau los ntawm starch?

A: Cyclodextrins (CDs) yog cyclic oligosaccharides tsim los ntawm cov hmoov txhuv nplej siab los ntawm fermentation. Kev sib xyaw ntawm dextrins tau los ntawm hydrolysis ntawm starch yog kho los ntawm ib qho tshwj xeeb enzyme, CD glycosyl transferase (CGTase) muaj peev xwm catalyze lub cyclization ntawm linear maltooligosacharides kom tawm los CDs.

Q: Dab tsi yog cov khoom ntawm natural cyclodextrins?

A: Cyclodextrins (CDs) yog non-toxic, qab zib polymers uas ruaj khov hauv dej thiab qee cov kuab tshuaj organic. Lawv qhia kev ruaj ntseg nyob rau hauv alkaline tej yam kev mob; cov kev tshaj tawm pKa qhov tseem ceeb ntawm cov CDs ntuj yog li ntawm 12.1 thiab 13.5.

Q: Dab tsi yog qhov sib txawv ntawm cyclodextrins?

A: Raws li tau hais dhau los, muaj peb hom cyclodextrin, uas yog, Alpha , Beta , thiab Gamma tseem hu ua thawj lossis niam txiv tiam CDs. Vim muaj cov piam thaj qaum hauv lawv lub moj khaum, lawv tuaj yeem raug txheeb xyuas tias yog cycloamyloses lossis dextrins.

Q: Dab tsi yog cov qauv molecular ntawm cyclodextrin?

A: Hom cyclodextrins yog tsim los ntawm 6-8 glucopyranoside units. Cov subunits no txuas nrog 1,4 glycosidic bonds. Cov cyclodextrins muaj cov duab toroidal, nrog qhov loj dua thiab qhov qhib me me ntawm toroid nthuav tawm rau cov kuab tshuaj theem nrab thiab thawj pawg hydroxyl raws li.

Q: Dab tsi yog daim ntawv thov ntawm ntuj cyclodextrins hauv kev lag luam kws tshuaj?

A: Hauv kev lag luam kws tshuaj, CDs tau siv los ua cov neeg ua haujlwm complexing los ua kom cov dej solubility ntawm cov tshuaj tsis zoo thiab ua kom lawv cov bioavailability thiab stability. CDs yog siv rau hauv kev siv tshuaj rau ntau lub hom phiaj, nrog rau kev txhim kho bioavailability ntawm cov tshuaj.

Q: Yuav siv cyclodextrin li cas hauv kev xa tshuaj?

A: CDs tau ua lub luag haujlwm tseem ceeb hauv kev tsim cov tshuaj tsis zoo dej-soluble los ntawm kev txhim kho cov tshuaj solubility pom zoo thiab / lossis kev sib cais los ntawm kev sib koom ua ke lossis cov khoom tawg, los ntawm kev ua raws li hydrophilic cab kuj rau cov tshuaj uas tsis txaus molecular yam ntxwv rau complexation, los yog raws li ntsiav tshuaj.

Q: Dab tsi yog cov cuab yeej zoo ntawm cyclodextrin inclusion complexes?

A: Kev tsim cov kev sib xyaw ua ke ntawm cov tshuaj thiab ntuj lossis hloov pauv cyclodextrins ua rau muaj dej solubility thiab txhim kho bioavailability ntawm cov tshuaj.

Q: Yuav ua li cas cyclodextrin txhim kho solubility ntawm cov tshuaj tsis zoo soluble?

A: Cyclodextrins (CDs) thiab lawv cov derivatives tuaj yeem txhim kho cov solubility ntawm cov tshuaj soluble tsis zoo los ntawm kev tsim cov complexes. Cov complexes encapsulate cov tshuaj insoluble, ua rau nws aqueous solubility. Lub complex dissociates thaum nws mus txog qhov chaw ntawm kev txiav txim.

Q: Ib qho piv txwv ntawm cyclodextrin yog dab tsi?

A: Piv txwv ntawm kev siv cyclodextrins hauv cov tshuaj hauv European lag luam yog -CD hauv cov ntsiav tshuaj cetirizine thiab cisapride suppositories, -CD hauv cov tshuaj minoxidil, thiab cov piv txwv ntawm kev siv -cyclodextrin derivatives yog SBE- -CD hauv cov hlab ntsha. antimycotic voriconazole, HP- -CD hauv cov tshuaj tiv thaiv kab mob itraconazole.

Q: Puas yog cyclodextrin yog ntuj lossis hluavtaws?

A: Cyclodextrins yog ntuj cyclic oligosaccharides uas ua lub luag haujlwm tseem ceeb hauv ntau qhov chaw xws li chaw muag tshuaj, tshuaj, chemistry, khoom siv, zaub mov lossis kev ua liaj ua teb.

Q: Dab tsi yog qhov kev txhawj xeeb txog kev nyab xeeb cuam tshuam nrog kev siv cyclodextrin hauv kev tsim tshuaj?

A: Thaum cyclodextrins txhim kho cov tshuaj nkag mus rau hauv lub qhov muag, qhov ntau ntawm 4% -CD thiab 5% RM- -CD tuaj yeem ua rau lub ntsej muag epithelium ntawm luav. Cov kev daws teeb meem ntawm 10% SBE- -CD thiab 12.5% HP- -CD pom tias tsis muaj tshuaj lom lossis khaus hauv qhov muag luav.

Q: Dab tsi yog lub luag haujlwm ntawm cyclodextrin hauv kev lag luam zaub mov thiab tsw?

A: Cyclodextrins (CDs) yog cyclic oligomers dav siv hauv kev tsim khoom noj ua khoom noj khoom haus ntxiv rau ntau lub hom phiaj, piv txwv li, txhawm rau txhim kho kev hnov lus zoo, txee lub neej, thiab kev sib cais ntawm cov khoom.

Q: Yuav siv cyclodextrin li cas hauv kev lag luam tshuaj pleev ib ce?

A: CDs tuaj yeem siv los ua cov tshuaj tsw qab sib txawv, suav nrog cov khoom tu tus kheej xws li tshuaj zawv plaub hau, deodorants, detergents thiab absorbent hmoov xws li da dej- thiab cov khoom me me-hmoov.

Q: cyclodextrin cuam tshuam li cas rau ib puag ncig?

A: Hauv cov qauv no, kev siv cov khoom sib txawv ntawm cyclodextrins (CDs) molecules tau nyiam cov xim zoo nkauj vim lawv paub zoo tias tsis muaj tshuaj lom, tsis muaj kev cuam tshuam ib puag ncig, thiab muaj peev xwm txo qis ib puag ncig thiab kev noj qab haus huv ntawm cov tshuaj tua kab.

Q: Dab tsi kub ntawm beta cyclodextrin decompose?

A: Cov neeg tshawb xyuas tus cwj pwm thermal ntawm -CD; Lub decomposition kub ntawm -cyclodextrin yog 250 degree los ntawm kev siv cov thermogravimetric tsom xam (TGA).

Q: Dab tsi yog kab noj hniav loj ntawm cyclodextrin?

A: {{0}} 60-0.65 nm. Raws li kev soj ntsuam crystallographic, nws ntseeg tau tias qhov loj me me ntawm -CD kab noj hniav ( puab kab 0 60-0.65 nm, sab nraud txoj kab uas hla 1.52 nm, thiab qhov siab 0.78 nm) ua rau nws zoo tagnrho. tus tswv tsev ntawm cov haiv neeg cyclodextrins rau suav nrog complex tsim moiety.

Q: Puas yog cyclodextrin soluble hauv dej?

A: -cyclodextrin muaj tsawg solubility hauv dej, thiab li no kev lag luam siv nws cov derivatives, xws li 2-hydroxypropyl- -cyclodextrin (HPbCD), randomly methylated -cyclodextrin (RAMEB), thiab -cyclodextrin sulfobutyl ether sodium ntsev (SBEbCD).

Q: Puas yog cyclodextrin FDA pom zoo?

A: Cyclodextrin Regulatory Status thiab Pharmaceutical Siv raws li Excipients. Ib haiv neeg cyclodextrins tau txais kev pom zoo los ntawm European Medicines Agency (EMA) thiab lawv muaj GRAS xwm txheej, piv txwv li, 'feem ntau lees paub tias muaj kev nyab xeeb' los ntawm US Food and Drugs Administration (FDA).

Q: Puas yog cyclodextrin muaj kev nyab xeeb rau daim tawv nqaij?

A: Yog, cyclodextrins kuj tseem muaj kev nyab xeeb thiab biocompatible, ua rau lawv muaj cov khoom zoo rau cov khoom siv tawv nqaij. Lawv tsis muaj tshuaj lom, tsis ua rau khaus, thiab tsis ua rau muaj kev fab tshuaj. Lawv kuj yog biodegradable thiab tsis nyob rau hauv ib puag ncig.

Peb paub zoo tias yog ib qho ntawm cov ua lag luam ntuj cyclodextrin thiab cov muag khoom hauv Suav teb. Yog hais tias koj yuav mus yuav zoo zoo ntuj cyclodextrin ntawm tus nqi sib tw, txais tos kom tau txais cov ntaub ntawv ntau ntxiv los ntawm peb lub hoobkas.