1.1 muaj cov khoom sib xyaw tshwj xeeb, thiab tuaj yeem tsim nrog cov tshuaj hydrophobic me me molecules ntawm inclusion complex soluble hauv dej
Cyclodextrinmuaj hydrophobic sab hauv kab noj hniav thiab ib tug hydrophilic nto vim nws structural yam ntxwv.Yog li ntawd, nws muaj cov yam ntxwv inclusion zog thiab muaj peev xwm tsim inclusion complexes nrog ntau yam khoom los ntawm tsis muaj zog kev sib cuam tshuam thiaj li hloov lub cev thiab tshuaj zog ntawm cov khoom molecules.At Tib lub sijhawm, vim tias tsis muaj toxicity thiab dej solubility ntawm cyclodextrin, cov kev sib xyaw ua ke tsim los ntawm cyclodextrin thiab hydrophobic me me tshuaj molecules tuaj yeem yaj hauv dej, yog li txhim kho cov tshuaj solubility, ua kom muaj kev ruaj ntseg ntawm cov tshuaj thiab txhim kho bioavailability thiab kev ua tau zoo. ntawm cov tshuaj.Thiab nws tso cai rau ntau cov tshuaj tiv thaiv rau qhov chaw hauv dej ua rau tag nrho cov khoom zoo ib puag ncig.
1.2 Tsis zoo stability rau cua sov, alkali thiab acid
CyclodextrinNws yog kub ruaj khov thiab tsis muaj qhov ntsuas kub ruaj khov. Nws pib decompose thaum rhuab mus txog 200 degree thiab tuaj yeem khaws cia rau lub sijhawm ntev ntawm chav sov.Stable rau alkali, tuaj yeem tsim ntsev ntawm pH siab; Nws tsis ruaj khov rau acid, hydrolysis tuaj yeem tshwm sim hauv cov kua qaub, thiab tus nqi. ntawm hydrolysis yog pom tseeb qeeb dua li cov hmoov txhuv nplej siab.Txawm li cas los xij, Cd yog ruaj khov hauv dilute acid ntawm chav tsev kub. Cd tsis yog hydrolyzed los ntawm -amylase, tab sis tuaj yeem maj mam hydrolyzed los ntawm -amylase. Feem ntau, lub nplhaib loj ntawm Cd, qhov ceev ntawm hydrolysis.
1.3 Nws yog ib qho nyuaj rau absorbed nyob rau hauv tib neeg lub cev thiab muaj me ntsis toxicity
Cyclodextrinvim yog cov molecules loj, nyob rau hauv tib neeg lub cev yog ntau nyuaj rau nqus, feem ntau ntawm cov thawj daim ntawv ntawm excretion; lub ntsiab qhov chaw ntawm nqus yog cov hnyuv me.Lub metabolism ntawm cyclodextrin yog tsuas yog ua tiav los ntawm cov colonic flora, thiab cov khoom kawg. yog CO2 thiab H2O. -CD yog qhov qeeb tshaj plaws thiab -CD yog qhov ceev tshaj plaws.Cyclodextrin muaj me ntsis toxicity rau biology thiab yuav luag tsis muaj toxicity tom qab kev tswj qhov ncauj.In parenteral siv, CD tuaj yeem cuam tshuam nrog cell membrane cov khoom, ua rau cov cell puas. Ntev mus sij hawm ntev ntawm cyclodextrin nyob rau hauv tib neeg lub cev yuav ua rau kom lub nra ntawm lub raum.
1.4 Pheej yig thiab yooj yim kom tau
Cov txheej txheem ntau lawm ntawm cyclodextrin yog qhov yooj yim, nws lub cev thiab tshuaj lom neeg muaj zog, thiab cov txheej txheem tsim khoom yog yooj yim thiab yooj yim kom tau txais.
