Sulfobutyl - -cyclodextrinsodium (SBE- -CD) yog ib qho derivative ntawm -cyclodextrin nrog cov saw hlau tsis zoo, uas ua rau muaj kev cuam tshuam tshwj xeeb nrog cov tshuaj raug them zoo. Nws tuaj yeem txhim kho cov dej solubility ntawm cov tshuaj hydrophobic tom qab encapsulation thiab txhim kho lawv qhov nqus hauv tib neeg lub cev, yog li txhim kho kev ruaj ntseg thiab lwm yam khoom. Tsis tas li ntawd, nws tuaj yeem tsim cov khoom siv tsis yog covalent nrog cov tshuaj molecules, yog li txhim kho kev nyab xeeb tshuaj, txo lub raum toxicity, txo cov tshuaj hemolysis, tswj cov tshuaj tso tawm, thiab npog cov ntxhiab tsw.SBE- -CDtau siv rau hauv cov tshuaj txhaj tshuaj, tshuaj qhov ncauj, tshuaj qhov ntswg, thiab tshuaj ocular, nthuav qhia tshwj xeeb affinity thiab encapsulation zog rau cov tshuaj muaj nitrogen. Tam sim no, FDA pom zooSBE- -CDCov tshuaj suav nrog rau kev txhaj tshuaj feem ntau suav nrog voriconazole (lub npe lag luam: Vfend), ziprasidone (lub npe lag luam: Geodon), thiab posaconazole (lub npe lag luam: Noxafil).
Shandong Binzhou Zhixuan Biotechnology Co., Ltd. yog lub tuam txhab thev naus laus zis uas tau tsim tshwj xeeb hauv kev tshawb fawb thiab tsim cov cyclodextrin thiab nws cov derivative series raws li cov tshuaj excipients, nrog rau cov khoom noj khoom haus, khoom noj khoom haus, thiab tshuaj pleev ib ce. Lub tuam txhab cov khoom tseem ceeb suav nrog hydroxypropyl beta-cyclodextrin thiab sulfobutyl beta-cyclodextrin sodium ntsev. Ntxiv mus, lub tuam txhab tuav kev koom tes nrog cov tsev kawm ntawv hauv tsev thiab txawv teb chaws thiab cov chaw tshawb fawb thiab tau txais FDA rau npe rau nws cov khoom. Nrog rau kev tsom mus rau kev tshawb fawb thiab kev ua tiav, peb tau cog lus los muab koj cov khoom lag luam zoo thiab cov kev pabcuam. Zhixuan txaus siab koom tes nrog koj rau kev sib nrig sib pab thiab yeej-yeej cov txiaj ntsig.
