Ntxiv solubility thiab bioavailability ntawm cov tshuaj
Tsim cov kev sib xyaw nrog cov tshuaj tsis zoo soluble tuaj yeem txhim kho lawv cov dej solubility hauv dej, ua rau kev txhim kho bioavailability thiab kev ua tau zoo, nrog rau kev tso cai rau kev tsim cov tshuaj txhaj tshuaj, yog li txo qhov xav tau ntau npaum. Cov yam ntxwv xws li qhov sib piv thiab hom cyclodextrin tebchaw, cov xwm txheej suav nrog, kev npaj cov txheej txheem ntawm cov complexes, thiab daim ntawv ntawm cov tshuaj tuaj yeem cuam tshuam rau kev solubility ntawm cov complexes. Tom qab encapsulated los ntawm -Cyclodextrin (-CD), cov tshuaj tsis zoo soluble muaj zog solubility thiab dissolution tus nqi nyob rau hauv dej, yog li txhim kho lawv bioavailability thiab kev ua tau zoo los ntawm kev yooj yim rau lawv nkag mus rau hauv cov hlab ntsha thiab cov hlab ntsha-hlwb barrier. Piv txwv li, lub solubility ntawm quercetin nce 12 zaug thiab qhov sib npaug ntawm kev sib cais nce 6 zaug tom qab encapsulation nrog-CD, tseem ceeb txhim kho bioavailability ntawm quercetin ntsiav tshuaj. Rutin, vim nws cov dej solubility tsis zoo thiab qhov nqus nqus ntawm qhov ncauj, tau txhim kho zoo heev ntawm kev solubility thiab bioavailability los ntawm kev tsim rutin - -CD complexes.
Txhim kho tshuaj stability
Cov tshuaj nquag ua rau oxidation, hydrolysis, lossis volatility tuaj yeem tiv thaiv los ntawm encapsulating qhov tsis ruaj khov nyob rau hauv cov kab noj hniav ntawm cyclodextrins, yog li tiv thaiv kev sib cuag nrog cov molecules ib puag ncig thiab tiv thaiv oxidation, hydrolysis, thiab volatilization, yog li ua kom ruaj khov. Piv txwv li, dihydroquercetin, heev volatile ntawm 40 degree nrog ib tug residual tus nqi ntawm tsuas yog 27% tom qab 10 hnub, tuav ib tug residual tus nqi ntawm ntau tshaj 95% thaum complex nrog -cyclodextrin nyob rau hauv tib yam mob. Ursofalk ntsiav tshuaj uas muaj ntau yam tsis hloov pauv roj yam xws li fennel thiab tangerine tev feem ntau pom cov roj me me rau ntawm qhov chaw thiab deteriorated rau hauv cov ntsiav tshuaj tsaus nti vim lawv cov volatility, ua rau tsis ruaj tsis khov. Txawm li cas los xij, tus txheej txheem tshiab ntawm encapsulating volatile roj nrog-CDovercame qhov teeb meem no, ho txhim kho qhov zoo ntawm cov ntsiav tshuaj. Tsis tas li ntawd, kev tsim cov CD complexes zam cov teeb meem sib haum xeeb hauv kev kho ua ke.
Ua haujlwm raws li cov neeg nqa khoom rau kev xa tshuaj mus tas li thiab lub hom phiaj
Cyclodextrins tuaj yeem ua raws li cov neeg nqa khoom rau kev khaws tshuaj, tswj kev tso tawm, thiab nce kev thauj khoom ntawm lipophilic tshuaj hauv microspheres, ua rau lub hom phiaj lossis tswj kev xa tshuaj. Lawv kuj tuaj yeem siv rau hauv kev tsim cov tshuaj uas tsis yog pH-nyob ntawm osmotic twj tso kua mis. Piv txwv li, hydroxypropyl - -cyclodextrin(HP{0}}CD)tau ua hauj lwm raws li cov khoom siv rau cov tshuaj magnetically tsom anticancer tshuaj doxorubicin, ua kom pom lub peev xwm rau kev xa cov tshuaj sib nqus los ntawm kev kawm lawv cov kev sib cuam tshuam thiab kev tsim cov khoom.
Txo cov tshuaj toxicity thiab irritation
Daim ntawv thov ntawm cyclodextrin complexes tuaj yeem npog cov ntxhiab tsw tsis zoo thiab txo cov kab mob plab hnyuv ntawm cov tshuaj uas muaj cov tshuaj tiv thaiv kab mob, tiv thaiv lawv cov tshuaj lom. Piv txwv li, podophyllum resin, muaj tshuaj lom thiab khaus heev, yog ib txwm ua tiav rau hauv podophyllum ointment tom qab tshem tawm cov roj feem ntau. Txawm li cas los xij, cov tshuaj pleev ib ce tseem pom muaj toxicity thiab irritation. Encapsulation nrog -CD txo nws txoj kev khaus khaus, thiab kev soj ntsuam xyuas pom tau tias txhim kho kev yooj yim ntawm kev siv thiab kev ua tau zoo txaus. Lei Gong Teng, tsob nroj muaj tshuaj lom nrog cov tshuaj tiv thaiv kab mob tseem ceeb thiab kev tiv thaiv kab mob, tau siv rau nws cov khoom kho mob thaum txo cov tshuaj lom los ntawm kev ntim khoom nrog -CD.
Powder ntawm volatile roj nyob rau hauv cov tshuaj suav tshuaj rau kev yooj yim formulation
Encapsulation ntawm cov roj volatile los ntawm cov tshuaj suav tshuaj tsis tsuas yog tiv thaiv lawv cov evaporation, yog li txuag kev ua tau zoo, tab sis kuj pab txhawb lawv hloov dua siab tshiab rau hauv cov hmoov khib nyiab, ua rau lawv haum rau ntau hom tshuaj. Piv txwv li, suav nrog cov roj tsis hloov pauv hauv kev tsim cov ntsiav tshuaj Brain-Ease txhim kho cov khoom ntws thiab tiv thaiv tsis muaj xim ntawm cov ntsiav tshuaj qab zib-coated thaum khaws cia.
