Tsis ntev los no, sulfobutyl ether cyclodextrin (sbecd) tau kos cov kev saib xyuas hauv tsev kho mob. Raws li cov sulfonic acid derivative ntawm - cyclodextrin, nws tau dhau los daws cov qauv hluav taws xob tsis zoo "vim nws cov qauv molecular thiab supramolecular tshuaj.
Kev tawg: los ntawm kev kuaj kom kuaj mob
SBECD qhia txog Sulugobutyl ether cov saw mus rau cov pawg hydroxyl ntawm txoj haujlwm 2, kev sib sau ua anionic, cov dej {{} soluble derivative. Nws cov molecular kab noj hniav yuav ua tiav immophobic tshuaj molecules, tsim ruaj khov tsis yog} kevalent compubility thiab ruaj khov. Piv txwv li, Pfizer txoj kev txhaj tshuaj ziprasidone, nrog kev pab ntawm SBECD thev naus laus zis, tau nce ntxiv rau cov solub zus ob peb zaug, ua rau yav dhau los- Txhim kho cov qauv tsim tau. Los ntawm 2025, 12 SBECD - Cov tshuaj tiv thaiv kab mob uas tau pom zoo thoob plaws ntiaj teb (remdesivir), thiab cov tshuaj antitumor), thiab cov tshuaj antitumor (carfilzomib), ntawm lwm yam.
Kev kuaj mob: dual kev hloov kho hauv kev nyab xeeb thiab ua tau zoo
Piv rau cov khoom siv rau cyclodextrins, SBECD tau qis dua cov ntsiab lus me me thiab tsis muaj zog hemolytic cov khoom. Kev tshawb fawb qhia tau tias nws tuaj yeem siv tshuaj ntxiv rau ib nrab ntawm- lub neej thiab nce bioavailability los inhibiting p ing {2} òcoprotein equlux. Piv txwv li, ntawm Tolfenpyrad suav nrog txoj kev sib cais, SBECD tau nce siab txog kev ua kom muaj ntshav ntau ntxiv los ntawm 40% thiab ntev ntev} lub neej los ntawm 2 teev. Ib qho ntxiv, sbecd tuaj yeem npog qhov tsis muaj pa tsw qab ntawm cov tshuaj thiab txo cov khoom siv rau cov khoom noj, muab kev paub ntau dua rau cov neeg mob.
Kev Tsim Nyog: Sawv ntawm Suav lag luam
Tam sim no, tsib sbecd cov tshuaj lom, suav nrog voriconazole thiab ziprasidone, tau tsim nyob rau hauv Suav teb, thiab ntau yam kev lag luam tau nrawm dua lawv cov txheej txheem. Cov kws tshaj lij qhia tias nrog kev loj hlob ntawm cov tshuaj kho mob thiab cov ntaub ntawv tso tawm loj, thiab yuav dhau los ua kev txhim kho ntawm cov tshuaj ntsuam kws tshuaj.
Los ntawm kuaj cov kev tsim kho tshiab rau cov ntaub ntawv kho mob, sulfobutyl ether cyclodextrin yog rov kho cov yeeb yaj kiab yav tom ntej nrog cov "zais kev sib tw".
