HydroxyPropyl-beta-cyclodextrin; Hydroxypropyl Betaccclodextrin yog hydroxylated derivative ntawm -cyclodextrin. Nws yog ib qho ntawm cov betacclodextrin derivchares uas tau kawm meej nyob rau hauv kev npaj tsis ntev los no ntawm kev npaj thiab kev ntsuam xyuas kev lom zem. Hydroxypropyl betaccchlodextrin Tsis tsuas yog muaj lub hnab ntawv zoo kawg nkaus ntawm ntau qhov sib txuas thiab cov tshuaj tso tawm siab thiab cov tshuaj sib xyaw ntawm cov tshuaj encapsulated hauv vivo. Yog li ntawd, hydroxypropyl Betaclodextrin muaj qee cov khoom tshwj xeeb zoo heev, thiab muaj cov ntawv thov dav dav thiab muaj kev thov siv ntau tshaj plaws hauv cov tshuaj.
Hydroxypropyl BetaccClodextrin yog ib qho kev ua yeeb yam ntawm BetaccClodextrin qhov twg C2, C3, thiab C8 hydroxyprropyl pab pawg. Vim muaj kev tawm tsam sib txawv, cov haujlwm ntawm hydroxypropyl sib txawv, yog li ob peb lub tshuab xws li {}} hydroxypropyl Betaccyrropyl yuav tsim tau.
Tom qab pab pawg hydroxylodextrin yog hloov los ntawm prinroxypopyl betaclodextrin ntxiv rau tib neeg, thiab lwm yam, nws tseem muaj cov yam ntxwv hauv qab no los ntawm betacccodextrin. Piv txwv li:
1, HydroxyPropyl Betaccclodextrin ntawm chav tsev kub, feem ntau ntau tshaj 50%, yog li nws tsis tuaj yeem yog cov tshuaj cawv hauv cov kua txiv aqueous.
2. Kev xaiv ntawm hydroxypropyl Betaclodextrin thiab betacclodextrin rau cov khoom siv hauv cov ntawv sib txawv ntawm cov khoom siv hauv cov khoom siv tau.
3, HydroxyPropyl Betaccchlodextrin yog tsis muaj catabolic hauv tib neeg lub cev, tsis muaj kev cuam tshuam, kev quav plaub ntug, kev ua yeeb yaj kiab ua yeeb yam, txhua tus ua zis.
4, Hydroxyprodropyl Betaccclodextrin nyob rau hauv lub cev lom neeg tuaj yeem txhawb kev tso tawm nrawm nrawm.
5, HydroxyPropyl BetaccClodextrin dua betacclodextrin lossis lwm yam kev ua yeeb yam (xws li methylation-betaccation-betaclation-betyrin), thiab muaj kev nyab xeeb dua.
Vim hais tias ntawm cov khoom saum toj no ntawm hydroxypropyl Betaclodextrin, nws tau txais ntau thiab ntau mloog hauv cov chaw tshuaj. Txhawm rau txhim kho cov neeg txoj kev nkag siab ntawm daim ntawv thov ntawm hydroxypropyl betacclodextrin, cov piv txwv hauv qab no yog lus qhia:
1. Nyob rau hauv cov nqe lus ntawm nce cov dej solubility ntawm insoluble yeeb tshuaj. Piv txwv li, DihydroAremisinin thiab Artemethete yog insoluble hauv dej, thiab lawv solubility tuaj yeem ua tau ntawm kev txhaj tshuaj ntawm cov hmoov kom zoo nrog 1 hydroxypropyl betacclodextrin. Lub solubility ntawm dioxin hauv 5 {{{{{}}}}}} Hydroxyprops nce los ntawm 0.07mg / ml rau 68mg / ml hauv dej.
2. Nyob rau hauv cov nqe lus ntawm kev txo cov tshuaj ruaj khov. Piv txwv li, tom qab Estradiol tau ntim nrog hydroxypropyl Betaccclec thiab muab tso rau ntawm chav tsev kub, nws lub neej ib nrab-lub neej tuaj yeem txuas ntxiv ntawm 1.2 xyoos mus rau 4 xyoos.
3, hauv kev txo cov kev mob tshwm sim ntawm cov tshuaj. Piv txwv li, lub vasodilator nimodipine yog insoluble hauv dej thiab yog qhov txaus qhia rau thawj daim kis ntawm daim siab ntawm daim siab thaum noj. Kev siv ntawm hydroxypropyl Betaclodextrin ua kev txhaj tshuaj rau kev tswj cov leeg nqaij tuaj yeem ua rau muaj kev puas tsuaj ntawm cov tshuaj thiab txo cov ntaub so ntswg.
4. Nyob rau hauv cov nqe lus ntawm kev txhim kho yeeb tshuaj muaj; Piv txwv li: Steroid Iormone yog hydroxypropyl betaclodextrin hnab ntawv, thiab piv nrog cov ntshav tawm, thiab kev tso tawm tshuaj nyob rau hauv cov ntshav yuav muaj li ntawm 2 zaug siab dua.
5. Hais txog kev nyab xeeb ntawm hydroxypropyl Betaclodextrin. Raws li cov txheej txheem subacute thiab cov kev tshawb fawb phem, hydroxypropropyl betaccclec tsis ua rau muaj mob lossis ua rau tuag nyob rau hauv nas. Tom qab kev txhaj tshuaj ntxiv rau luav, hydroxypropyl Betaclodextrin tau tshem tawm sai sai ntawm cov ntshav thiab ua rau cov zis sai sai, thiab muaj cov tsos mob tsis zoo tom qab txhaj tshuaj tas mus tas li. Kev tswj hwm lub luag haujlwm ntawm 200Mg / kg hydroxypropyl betaclodextrin tsis qhia cov kev kho mob hauv cov nas thiab liab. Qhov ncauj lossis cov tshuaj uas tau pom ntawm hydroxypropyl Betaclodextrin ib leeg tau nce li 15g / kg lossis 10g / kg, ntsig, thiab tsis tua liab. Cov kev tshawb fawb txog tib neeg tau qhia tias hydroxypropyl betadextrin yog muab cov kev cuam tshuam, thiab tsis muaj kev cuam tshuam nrog rau daim tawv nqaij, qhov muag, lossis cov leeg. Qhov no qhia tau hais tias hydroxypropyl betaclodextrin muaj kev nyab xeeb rau tsiaj muaj sia.
Hydroxypropyl betaccclodextrin yog qhov muaj kev nyab xeeb yog tias muab raws li lub rooj hauv qab no.
Cov tswj hwm txoj kev thiab koob tshuaj ntawm hydroxypropyl betacclodextrin rau tib neeg lub cev 1. Tag nrho cov nyiaj ntawm kev Infusenous Txoj kev lis ntshav: 30G. Txoj kev siv: 5% rau 4 hnub sib law liag
2, tag nrho cov nyiaj ntawm kev txhaj tshuaj tiv thaiv kev txhaj tshuaj: 3G txhua qhov tshuaj: 150mg / Kg siv txoj kev: 5% rau 4 hnub sib law liag
3, feem pua) tag nrho siv: {0. 2g / kg ib koob tshuaj: {}}. 2mg / kg txoj kev siv: ntsiav tshuaj
4. Tag Nrho Kev Siv Nasal: 600Mg / Hnub Txhua Qhov Tshuaj: 40mg / Hnub Txheej Txheem Siv: 10% aqueous kev daws
5, Qhov ncauj tshem tawm tag nrho cov nyiaj: 120mg / kg txhua koob tshuaj: 120mg / Kg siv txoj kev: ntsiav tshuaj
6. Kev siv tawv: 45% aqueous daws
Ntawm qhov tod tes, vim muaj cov kev ua haujlwm ntawm Hydrolysis thiab cov leeg ua rau tawv nqaij thiab cov leeg nqaij, nws tsis yog kev cuam tshuam thaum txhaj rau cov leeg nqaij. Hydroxypropyl Betaccclodextrin yog qhov zoo dua rau lwm cov neeg nplua nuj nyob hauv cov kev hwm.
