hydroxylpropyl - -cyclodextrin(HP- -CD) yog lwm txoj hauv kev rau -, - thiab -cyclodextrin, nrog kev txhim kho cov dej solubility thiab tej zaum yuav muaj toxicologically benign.
Muaj kev kawm ntawdHP - -CDNws raug pom zoo nyob rau hauv cov tsiaj uas tau sim (nas, nas thiab dev), tshwj xeeb tshaj yog thaum txhaj tshuaj ntawm qhov ncauj, thiab qhia tias tsuas yog txwv tsis pub muaj tshuaj lom. Hauv kev tshawb fawb luv luv, muaj kev hloov pauv biochemical me ntsis thaum cov kev tshawb fawb ntawm lub sijhawm ntev, mus txog peb lub hlis, ua rau muaj kev hloov pauv me me ntawm hematological ntxiv tab sis tsis muaj kev hloov pauv histopathological. Thaum txhaj tshuaj intravenously, cov kev hloov histopathological tau pom nyob rau hauv lub ntsws, daim siab thiab lub raum tab sis tag nrho cov kev tshawb pom tau thim rov qab thiab tsis muaj qhov cuam tshuam tau tiav. Cov kev tshawb fawb carcinogenicity tau pom tias muaj cov qog nqaij hlav hauv nas hauv cov txiav thiab cov hnyuv uas ob leeg suav tias yog cov nas tshwj xeeb. Kuj tseem muaj cov kev hloov pauv uas tsis yog carcinogenic tau sau tseg hauv cov zis, tab sis cov kev hloov pauv no kuj thim rov qab thiab tsis ua rau lub raum tsis ua haujlwm. Tsis muaj kev cuam tshuam rau kev loj hlob ntawm embryo-foetal hauv cov nas lossis luav.
HP - -CDtau pom tias muaj kev zam zoo rau tib neeg, nrog rau qhov tshwm sim tsis zoo tshwm sim yog raws plab thiab tsis muaj qhov tshwm sim tsis zoo ntawm lub raum ua haujlwm, tau sau tseg rau hnub no.
