Hydroxypropyl-beta-cyclodextrin (HP CD) Thiab Risperidone Tau Electrospun Rau Hauv Nanofibrous Zaj Duab Rau Kev Muaj Peev Xwm Ceev-disintegrating Drug Delivery System

Hydroxypropyl-beta-cyclodextrin (HP CD)thiab risperidone tau electrospun rau hauv nanofibrous zaj duab xis rau lub peev xwm ceev-disintegrating tshuaj xa system. Risperidone yog siv los kho kev puas siab puas ntsws bipolar, schizophrenia, thiab mus ob peb vas hloov ntawm autism. Txawm li cas los, nws yog xyaum insoluble nyob rau hauv aqueous nruab nrab. Ntawm qhov tod tes, qhov encapsulation ntawm risperidone rau hauv HP CD kab noj hniav los ntawm kev sib xyaw ua ke tuaj yeem txhim kho cov dej solubility ntawm cov tshuaj molecule. Cov tshuab IC tau npaj nrog 4/1 thiab 2/1 M piv (HP CD / risperidone). Cov tshuaj nquag HP CD aqueous daws (200%, w / v) tau siv rau kev tsim fiber ntau. Thaum kawg, lub kaw lus muaj qhov sib piv 4/1 M ua rau muaj qhov tseeb thiab homogeneous tov uas qhia tias HP CD thiab risperidone ua tiav IC. Txawm li cas los xij, HP CD / risperidone-IC muaj 2/1 M piv yog turbid thiab muaj qee qhov me me ntawm qhov tsis sib xws ntawm risperidone. Txawm li ntawd los, cov yeeb yaj kiab dawb-sawv thiab nyias nanofibrous tau txais rau ob lub tshuab nrog qhov nruab nrab fiber ntau txoj kab uas hla ntawm ∼315 nm thiab ∼280 nm rau 2/1 thiab 4/1 systems, feem. Ob HP CD / risperidone-IC nanofibers tau tsim nrog kwv yees li 100% khaws cia ntawm risperidone nyob rau hauv nanofiber matrix yam tsis tau poob ntawm risperidone thaum lub sij hawm electrospinning txheej txheem, uas yog, HP CD / risperidone-IC nanofibers khaws cia thawj M piv ntawm 2/1 thiab 4/1 raws li hauv electrospinning tov. Ob lub HP CD / risperidone-IC nanofibrous zaj duab xis tau pom sai-disintegration thiab ceev-tso cov yam ntxwv nyob rau hauv cov qaub ncaug dag thiab aqueous nruab nrab txheeb xyuas lawv lub peev xwm raws li ib tug ceev-disintegrating qhov ncauj tshuaj xa system rau risperidone.