Daim ntawv thov ntawmcyclodextrin muajhauv khw muag tshuaj
1.1 Ua kom cov solubility thiab bioavailability ntawm cov tshuaj
Cov tshuaj insoluble tuaj yeem ua rau hauv kev suav nrog txhawm rau txhim kho lawv cov solubility hauv dej thiab tuaj yeem ua rau hauv kev txhaj tshuaj ntxiv txhawm rau txhim kho bioavailability ntawm cov tshuaj txhawm rau txhim kho lawv cov potency thiab txo cov koob tshuaj.Thaum cov tshuaj cyclodextrins suav nrog cov tshuaj kom nce ntxiv. Solubility ntawm cov tshuaj, qhov kev faib ua feem thiab hom cyclodextrins, inclusion tej yam kev mob, txoj kev npaj ntawm lub inclusion compound thiab daim ntawv ntawm lub xub ntiag ntawm cov tshuaj yuav tag nrho cov muaj feem xyuam rau lub solubility ntawm lub inclusion compound.-CDtuaj yeem ua rau kom cov tshuaj solubility hauv dej thiab qhov kev sib cais ntawm qhov kev npaj. Txij li thaum lub inclusion complex yog nyob rau hauv ib tug molecular lub xeev, nws yog ib qho yooj yim mus dhau los ntawm cov roj ntsha cell membrane thiab cov ntshav-cerebrospinal kua barrier, yog li kev txhim kho cov bioavailability thiab kev ua tau zoo ntawm cov tshuaj.Piv txwv li, solubility ntawm oleanolic acid los ntawm-CDnce los ntawm 12 lub sij hawm thiab cov cumulative dissolution tus nqi nce los ntawm 6 lub sij hawm, uas zoo heev txhim kho lub bioavailability ntawm oleanolic acid ntsiav tshuaj.Cov ntawv thov ntawm rutin tau cuam tshuam los ntawm cov dej tsis zoo solubility thiab qhov ncauj nqus nqus. Txawm li cas los xij, solubility ntawm rutin -CD hauv dej tau nce los ntawm 13 npaug, uas txhim kho bioavailability ntawm cov tshuaj.
1.2 Txhim kho tshuaj stability
Thaum cov tshuaj oxidized yooj yim, hydrolyzed thiab volatile tshuaj raug tsim rau hauv-CDinclusion complex, lub unstable ib feem ntawm cov tshuaj molecule yog encapsulated nyob rau hauv lub -CD qhov, yog li txiav tawm kev sib cuag nyob ib ncig ntawm cov tshuaj molecule thiab tiv thaiv cov tshuaj molecule, zoo tiv thaiv oxidation, hydrolysis thiab volatilization, yog li ua rau stability.Piv txwv li, paeonol. yog volatile heev, thiab cov seem seem ntawm paeonol- -CD tsuas yog 27% tom qab muab tso rau ntawm 40 degree rau 10 hnub, thaum cov seem seem ntawm paeonol- -CD yog tseem tshaj 95% nyob rau hauv tib yam. Tej yam kev mob.Lub Nisaitong ntsiav tshuaj muaj ntau yam volatile roj Cheebtsam, xws li cumin, tangerine tev, thiab lwm yam. Thawj txheej txheem kev npaj yog tshuaj tsuag cov volatile roj ncaj qha mus rau hauv cov khoom qhuav thiab ces nias lub ntsiav tshuaj kom cov ntsiav tshuaj nto feem ntau muaj roj me ntsis. . Qhov zoo ntawm cov ntsiav tshuaj tsis ruaj tsis khov yog tias lub sijhawm ntev dua.Lub tshuab tshiab ntawm -CD encapsulation ntawm cov roj tsis hloov pauv overcomes lub phenomenon ntawm cov roj seepage thiab zoo heev txhim kho qhov zoo ntawm kev npaj.Ntxiv rau, incompatibility contraindication ntawm kev sib xyaw tshuaj tau zam. vim qhov tsim ntawm CD suav nrog complex.
1.3 Raws li tus neeg nqa khoom rau kev tso tawm thiab cov phiaj xwm npaj
Incapsulation ntawm cyclodextrins nrog cov tshuaj kom ua tiav cov tshuaj cia thiab tswj cov tshuaj tso tawm kuj tuaj yeem ua rau cov tshuaj lipophilic hauv nanocapsules ua rau nws muaj peev xwm npaj nanocapsules rau lub hom phiaj lossis tswj kev tso tawm thiab tuaj yeem siv rau hauv osmotic twj npaj los tsim PH nyob ntawm osmotic twj tso kua mis ntsiav tshuaj. .HP - -CDNrog qis hemolysis thiab tsis tshua muaj khaus tau siv los ua cov khoom siv pob txha rau cov neeg nqa khoom ntawm cov khoom sib nqus tsom rau cov tshuaj antitumor doxorubicin los kawm nws cov kev cuam tshuam nrog cov tshuaj tiv thaiv qog, tshwj xeeb tshaj yog cov khoom ntawm kev suav nrog kev tsim.
1.4 Txo cov tshuaj lom thiab kev phiv ntawm cov tshuaj thiab txo qhov khaus
Ntau cov tshuaj muaj cov tshuaj tiv thaiv kab mob uas muaj tshuaj lom thiab cov kev mob tshwm sim, uas tsis tsuas yog cuam tshuam rau kev siv tshuaj, tab sis kuj cuam tshuam rau kev kho mob ntawm cov tshuaj. Txawm li cas los xij, daim ntawv thov ntawm cyclodextrin suav nrog tuaj yeem npog nws cov ntxhiab tsw phem thiab txo nws qhov khaus rau hauv plab hnyuv kom zoo kov yeej cov tshuaj toxicity.Croton yog cov dej khov heev - cov tshuaj uas tau tsav muaj cov tshuaj lom neeg loj.Rau kom txo tau cov tshuaj toxicity thiab alleviate laxative. cov nyhuv, cov kev cai ib txwm muaj yog tshem tawm feem ntau ntawm cov roj los ntawm croton taum thiab ua croton taum qab zib rau hauv cov tshuaj.Txawm li cas los xij, Croton taum qab zib tseem muaj qee qhov tsis zoo, xws li kev mob toxicity thiab muaj zog khaus. Tom qab uaB-CDsuav nrog compound, qhov irritation tau txo. Kev soj ntsuam xyuas pom tau tias qhov sib xyaw ua ke tau yooj yim siv thiab cov txiaj ntsig tau txaus siab.Tripterygium wilfordii yog cov nroj tsuag tshuaj lom, tab sis nws muaj cov txiaj ntsig tseem ceeb ntawm kev tiv thaiv kab mob tiv thaiv kab mob thiab tau siv dav hauv tsev kho mob.Yuav kom kov yeej nws cov tshuaj lom,-CDsuav nrog tuaj yeem txo nws cov toxicity thiab txhim kho nws txoj kev kho mob.
1.5 Ua kom cov roj tsis hloov pauv kom yooj yim rau kev npaj
Kev koom ua ke ntawm cyclodextrin rau hauv cov roj tsis hloov pauv ntawm cov tshuaj suav tshuaj tuaj yeem tsis tsuas yog tiv thaiv cov roj tsis muaj zog los ntawm volatilization thiab cuam tshuam rau cov nyhuv curative, tab sis kuj ua rau nws ua cov hmoov ua rau ntau hom tshuaj.Cov borneol menthol hauv Naoliqing ntsiav tshuaj fused nrog. sib sib zog nqus ua kua, uas ua rau lub fluidity ntawm granules tsis zoo. Loose flakes, pored nto thiab qhov hnyav sib txawv tau yooj yim tsim thaum nias cov ntsiav tshuaj. Cov icing txheej ntawm cov ntsiav tshuaj hloov xim thaum lub sijhawm khaws cia, thiab cov khoom sib xyaw ua ke tuaj yeem txhim kho tau zoo thaum ntxiv.
